Message from the Chief
Mark Ratcliffe, M.D.
Professor and Vice-Chair, Department of Surgery,
UCSF
Chief of Surgery, San Francisco VA Medical Center
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Funding in Cardiothoracic Surgical Research
Parity for surgeon-scientists in research funding is critical for the development of new procedures and devices.
Julius M. Guccione, Ph.D.
Associate Professor of Surgery
Contact Information
San Francisco, CA 94121
Education
- 1985, Tulane University, New Orleans, BS
- 1985-1987, University of California, San Diego, MS
- 1985-1990, University of California, San Diego, PhD
Research Interests
- Stem cell transplantation on the biophysics of cardiac function
Biography
Dr. Guccione studies the role of stem cell transplantation on the biophysics of cardiac function and the use of mechanical engineering principles in the diagnosis and treatment of cardiac disease. He is Co-director of the SFVAMC Cardiac Biomechanics Laboratory, which uses a combination of mathematical modeling and animal experiments to determine the effect of cardiac surgery on left ventricular function and remodeling. He is also a Core member of the UCB/UCSF Joint Graduate Group in Bioengineering. Current projects involve testing and validating a software tool for determining myocardial material properties in-vivo from cardiac catheterization and magnetic resonance imaging, and determining the effects of three different surgical treatments on function and regional mechanics in sheep.
Selected Publications
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Zahalak, G.I., de Laborderie, V., and Guccione, J.M., "The Effects of Cross-Fiber Deformation on Axial Fiber Stress in Myocardium," ASME Journal of Biomechanical Engineering, 1999, Vol. 121, pp. 376-385
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Guccione, J.M., Moonly, S.M., Moustakidis, P., Costa, K.D., Moulton, M.J., Ratcliffe, M.B., and Pasque, M.K., "Mechanism Underlying Mechanical Dysfunction in the Border Zone of Left Ventricular Aneurysm: A Finite Element Model Study," Annals of Thoracic Surgery, 2001, Vol. 71, pp. 654-662.
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Walker, J.C., Ratcliffe, M.B., Zhang, P., Wallace, A.W., Fata, B., Hsu, E.W., Saloner, D., and Guccione, J.M., "MRI-Based Finite-Element Analysis of Left Ventricular Aneurysm," American Journal of Physiology, 2005, Vol. 289, pp. H692-H700.
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Guccione, J.M., Walker, J.C., Bietler, J.R., Moonly, S.M., Zhang, P., Guttman, M.A., Ozturk, C., McVeigh, E.R., Wallace, A.W., Saloner, D.A., and Ratcliffe, M.B., "The Effect of Anteroapical Aneurysm Plication on End-Systolic Three-Dimensional Strain in the Sheep: A Magnetic Resonance Imaging Tagging Study," Journal of Thoracic and Cardiovascular Surgery, 2006, Vol. 131, pp. 579-586.
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Wall, S.T., Walker, J.C., Healy, K.E., Ratcliffe, M.B., and Guccione, J.M., "Theoretical Impact of the Injection of Material into the Myocardium: A Finite Element Model Simulation," Circulation, 2006, Vol. 114, pp. 2627-2635.
