Biography
Dr. Elaine Tseng is Professor of Surgery in the Division of Cardiothoracic Surgery at University of California San Francisco Medical Center. Her clinical expertise includes minimally invasive aortic valve replacement with Y-root enlargement, Ross operation, aortic surgery including ascending thoracic aortic aneurysm repairs, valve sparing aortic root replacements, structural heart disease—transcatheter aortic valve replacement and transcatheter edge-to-edge repair, and multi-arterial coronary artery bypass grafting.
Dr. Tseng grew up in North Carolina where she attended the North Carolina School of Science and Mathematics. She was a National Merit Scholar. She completed her undergraduate Bachelor of Science at the Massachusetts Institute of Technology where she graduated Phi Beta Kappa with a GPA 5.0. She earned her medical degree at Harvard Medical School and was one of three recipients per year of the Virginia A. Linnane Scholarship. Dr. Tseng underwent her general surgery training at The Johns Hopkins Hospital, where she received the George D. Zeidema Surgery Award and the Vincent L. Gott Cardiac Surgery Award. She was inducted into the Alpha Omega Alpha Honor Society and was awarded the Nina Braunwald Research Fellowship Award from The Thoracic Surgery Foundation for Research and Education. She also received the Hawley H. Seiler MD Award from the Southern Thoracic Surgical Association. Dr. Tseng underwent her clinical and advanced training in cardiothoracic surgery at The Johns Hopkins Hospital.
After completing her education and training, she joined the cardiac surgery staff at the UCSF and SFVA Medical Centers in 2002. Her academic research interests over the past 20 years have involved biomechanics, fluid dynamics, and computational simulations of aortic root surgery, including aortic stenosis, transcatheter aortic valves, Ross operation, ascending thoracic aortic aneurysm (aTAA) and dissection. She has been NIH R01 funded surgeon-scientist investigating the biomechanics of ascending thoracic aortic aneurysms to determine better predictors of type A dissection than maximum diameter. She is currently funded through a VA Merit award to investigate the impact of aTAA biomechanics on dissection, rupture, and all-cause mortality. She is the UCSF/SFVA site-principal investigator for the multi-institutional international randomized trial of treatment of ascending thoracic aortic aneurysms, TITAN trial, early surgery vs surveillance for 5.0-5.4cm aneurysms. She has published >100 scientific papers and book chapters. Dr. Tseng serves on the Society of Thoracic Surgeons (STS) Workforce on New Technology, American Association for Thoracic Surgery (AATS) Clinical Practice Standards Committee. She is on the Board of Directors of the Heart Valve Society, and the Thoracic Surgery Foundation. She is the Vice-Chair of the Cardiovascular Surgery and Anesthesia Council of the American Heart Association and is Senior Editor in the Editorial Board of Annals of Thoracic Surgery. She is a fellow of the American College of Surgeons and the American Heart Association and is certified by the American Board of Surgery and the American Board of Thoracic Surgery.
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California | Diversity, Equity, and Inclusion Champion Training | 2018 | |
Lenox Hill Hospital | Fellowship | Endovascular/Interventional Cardiology | 2006 |
Johns Hopkins Hospital | Fellowship | Cardiac Surgery | 2000 |
Johns Hopkins Hospital | Research Fellowship | Cardiac Surgery | 1997 |
Johns Hopkins Hospital | Residency | General Surgery | 1995 |
Johns Hopkins Hospital | Internship | General Surgery | 1994 |
Harvard Medical School | M.D. | Health Sciences and Technology (HST) Division | 1993 |
Massachusetts Institute of Technology | B.S. | 1989 |
Board Certifications
American Board of Surgery, 2000
American Board of Thoracic Surgery, 2003
Clinical Expertise
Acute and chronic type B aortic dissections
Aortic arch aneurysms
Aortic valve surgery
Ascending aortic and arch surgery
Endovascular repair of descending thoracic aortic aneurysm
Hypothermic circulatory arrest (HCA)
Marfan syndrome
Maze procedure for atrial fibrillation
Maze procedure for atrial fibrillation
Minimally invasive valve surgery
Off-pump coronary artery bypass
Reoperative cardiac surgery
Robotic cardiac surgery
Clinical Trials
- Related Conditions: Aneurysm| Start Date: | End Date:
Grants and Funding
- Developing Biomechanical Predictors of Ascending Thoracic Aortic Aneurysm Growth and Dissection | Veteran Affairs | 2022-04-01 - 2026-04-01 | Role: Principal Investigator
- Development of a System to Remove and Replace Transcatheter Heart Valves Percutaneously | Veterans Affairs | 2023-04-01 - 2024-03-31 | Role: Principal Investigator
- Improved Rupture Risk Assessment of Ascending Thoracic Aortic Aneurysms: Application of Patient-specific Modeling and Biomechanics | Marfan Fundation | 2020-02-15 - 2023-06-30 | Role: Principal Investigator
- Biomechanical Understanding of Ascending Thoracic Aortic Aneurysms | NIH | 2015-04-01 - 2021-03-31 | Role: Principal Investigator
Research Interests
Publications
- In Vivo Quantification of Ascending Thoracic Aortic Aneurysm Wall Stretch Using MRI: Relationship to Repair Threshold Diameter and Ex Vivo Wall Failure Behavior.| | PubMed
- Saphenous Vein Graft Pseudoaneurysm Treated With Covered Stenting.| | PubMed
- Temporal evolution of ascending aortic aneurysm wall stress predicts all-cause mortality.| | PubMed
- Evaluating the safety and efficacy of a novel polysaccharide hemostatic system during surgery: A multicenter multispecialty prospective randomized controlled trial.| | PubMed
- Impact of nondiameter aortic indices on surgical eligibility: Results from the Treatment in Thoracic Aortic Aneurysm: Surgery Versus Surveillance (TITAN: SvS) randomized controlled trial.| | PubMed
- Minimally invasive aortic valve replacement with Y-incision aortic root enlargement.| | PubMed
- Height and body surface area versus wall stress for stratification of mid-term outcomes in ascending aortic aneurysm.| | PubMed
- Reimplantation vs Remodeling: End of the Debate?| | PubMed
- Impact of Oral Anticoagulation on Clinical Outcomes in Postoperative Atrial Fibrillation.| | PubMed
- Sex differences in ascending aortic size reporting and growth on chest computed tomography and magnetic resonance imaging.| | PubMed
- Navigating Promotion in Thoracic Surgery.| | PubMed
- Ascending thoracic aortic aneurysm size at presentation and growth by diameter.| | PubMed
- Perspectives on the 2022 joint guidelines on the diagnosis and management of aortic disease.| | PubMed
- 2022 ACC/AHA guideline for the diagnosis and management of aortic disease: A report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.| | PubMed
- Aortic area/height ratio, peak wall stresses, and outcomes in veterans with tricuspid versus bicuspid aortic valve-associated ascending thoracic aortic aneurysms.| | PubMed
- Ascending thoracic aortic aneurysm elongation occurs in parallel with dilatation in a nonsurgical population.| | PubMed
- Formal consensus study on surgery to replace the aortic valve in adults aged 18-60 years.| | PubMed
- Regional and directional delamination properties of healthy human ascending aorta and sinotubular junction.| | PubMed
- 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.| | PubMed
- 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.| | PubMed
- Midterm Durability and Structural Valve Degeneration of Transcatheter Aortic Valve Replacement in a Federal Facility.| | PubMed
- Proximal Aortic Surgery in Women-We Need to Do Better.| | PubMed
- Association of 3-Year All-Cause Mortality and Peak Wall Stresses of Ascending Thoracic Aortic Aneurysms in Veterans.| | PubMed
- Regional wall stress differences on tricuspid aortic valve-associated ascending aortic aneurysms.| | PubMed
- Eptifibatide bridging therapy for staged carotid artery stenting and cardiac surgery: Safety and feasibility.| | PubMed
- Under Pressure-To See or Not To See.| | PubMed
- Ascending thoracic aortic aneurysm growth is minimal at sizes that do not meet criteria for surgical repair.| | PubMed
- Restrictive versus liberal transfusion in patients with diabetes undergoing cardiac surgery: An open-label, randomized, blinded outcome evaluation trial.| | PubMed
- Time to Remove the Left Atrial Appendage at Surgery: LAAOS III in Perspective.| | PubMed
- Wall stresses of early remodeled pulmonary autografts.| | PubMed
- Patient-Specific Biomechanics in Marfan Ascending Thoracic Aortic Aneurysms.| | PubMed
- Regional biomechanical and failure properties of healthy human ascending aorta and root.| | PubMed
- Discussion.| | PubMed
- Minimally invasive surgical aortic valve replacement in setting of pseudoxanthoma elasticum.| | PubMed
- Association of diameter and wall stresses of tricuspid aortic valve ascending thoracic aortic aneurysms.| | PubMed
- Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer.| | PubMed
- Development of the Minimalist Approach for Transcatheter Aortic Valve Replacement at a Veterans Affairs Medical Center.| | PubMed
- Impact of Transcatheter Aortic Valve Size on Leaflet Stresses: Implications for Durability and Optimal Grey Zone Sizing.| | PubMed
- Commentary: Virtual thoracic endovascular aortic repair for type A aortic dissection: Engineering transforms clinical reality.| | PubMed
- Long-term outcomes after transcatheter aortic valve implantation in failed bioprosthetic valves.| | PubMed
- Reply from authors: Aortic aneurysm biomechanics: Perfect is the enemy of good.| | PubMed
- Stent and leaflet stresses across generations of balloon-expandable transcatheter aortic valves.| | PubMed
- Wall Stress Distribution in Bicuspid Aortic Valve-Associated Ascending Thoracic Aortic Aneurysms.| | PubMed
- Wall stress analyses in patients with ≥5 cm versus <5 cm ascending thoracic aortic aneurysm.| | PubMed
- Outcomes of Veterans Undergoing TAVR Within Veterans Affairs Medical Centers: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program.| | PubMed
- Veterans Affairs Heart Team Experience With Transcatheter Aortic Valve Replacement and Minimally Invasive Surgical Aortic Valve Replacement.| | PubMed
- Evolution of Minimally Invasive Surgical Aortic Valve Replacement at a Veterans Affairs Medical Center.| | PubMed
- Evolution of Bilateral Mammary Arterial Grafting Program in Veterans Affairs Medical Center.| | PubMed
- Range of Pulmonary Autograft Responses to Systemic Pressure Immediately After Ross Procedure.| | PubMed
- Randomized Trial of Endoscopic or Open Vein-Graft Harvesting for Coronary-Artery Bypass.| | PubMed
- Factors associated with early dropout in an employer-based commercial weight-loss program.| | PubMed
- Long-term retention in an employer-based, commercial weight-loss programme.| | PubMed
- Stent and leaflet stresses in 26-mm, third-generation, balloon-expandable transcatheter aortic valve.| | PubMed
- Wall stress on ascending thoracic aortic aneurysms with bicuspid compared with tricuspid aortic valve.| | PubMed
- Evolution of Veterans Affairs Transcatheter Aortic Valve Replacement Program: The First 100 Patients.| | PubMed
- Impact of Patient-Specific Material Properties on Aneurysm Wall Stress: Finite Element Study.| | PubMed
- Gated thoracic magnetic resonance angiography at 3T: noncontrast versus blood pool contrast.| | PubMed
- Stent and Leaflet Stresses in 29-mm Second-Generation Balloon-Expandable Transcatheter Aortic Valve.| | PubMed
- Leaflet Mechanical Properties of Carpentier-Edwards Perimount Magna Pericardial Aortic Bioprostheses.| | PubMed
- Ferumoxytol MRA for transcatheter aortic valve replacement planning with renal insufficiency.| | PubMed
- Stent and leaflet stresses in a 26-mm first-generation balloon-expandable transcatheter aortic valve.| | PubMed
- Biomechanics of Failed Pulmonary Autografts Compared to Native Aortic Roots.| | PubMed
- In vitro evaluation of implantation depth in valve-in-valve using different transcatheter heart valves.| | PubMed
- Biomechanics of Failed Pulmonary Autografts Compared With Normal Pulmonary Roots.| | PubMed
- Suture Forces for Closure of Transapical Transcatheter Aortic Valve Replacement: A Mathematical Model.| | PubMed
- Vascular Operations Performed by Cardiothoracic Surgeons: The Society of Thoracic Surgeons Survey.| | PubMed
- When valve-in-valve implantation is not sufficient: Bioprosthetic Russian dolls.| | PubMed
- Flow-Induced Damage to Blood Cells in Aortic Valve Stenosis.| | PubMed
- Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.| | PubMed
- Bicuspid Aortic Valve-Associated Ascending Thoracic Aortic Aneurysm: Patient-Specific Finite Element Analysis.| | PubMed
- In Vitro Kinetic Characterization of Axitinib Metabolism.| | PubMed
- Proof of concept of FOLDAVALVE, a novel 14 Fr totally repositionable and retrievable transcatheter aortic valve.| | PubMed
- Ascending thoracic aortic aneurysm wall stress analysis using patient-specific finite element modeling of in vivo magnetic resonance imaging.| | PubMed
- Development of a Veterans Affairs hybrid operating room for transcatheter aortic valve replacement in the cardiac catheterization laboratory.| | PubMed
- Extended 3D approach for quantification of abnormal ascending aortic flow.| | PubMed
- Patient-specific finite element analysis of ascending thoracic aortic aneurysm.| | PubMed
- Successful percutaneous management of partial avulsion of the native aortic valve complex complicating transcatheter aortic valve replacement.| | PubMed
- Systolic flow displacement correlates with future ascending aortic growth in patients with bicuspid aortic valves undergoing magnetic resonance surveillance.| | PubMed
- Human pulmonary autograft wall stress at systemic pressures prior to remodeling after the Ross procedure.| | PubMed
- Feasibility of asymmetric stretch assessment in the ascending aortic wall with DENSE cardiovascular magnetic resonance.| | PubMed
- Invited commentary.| | PubMed
- Biomechanical properties of human ascending thoracic aortic aneurysms.| | PubMed
- Biventricular finite element modeling of the Acorn CorCap Cardiac Support Device on a failing heart.| | PubMed
- Magnetic resonance measurement of turbulent kinetic energy for the estimation of irreversible pressure loss in aortic stenosis.| | PubMed
- Identification of multiple 5-HT₄ partial agonist clinical candidates for the treatment of Alzheimer's disease.| | PubMed
- Improved preclinical cardiovascular therapeutic indices with long-term inhibition of norepinephrine reuptake using reboxetine.| | PubMed
- Material properties of CorCap passive cardiac support device.| | PubMed
- Imaging biomarkers of aortic disease: increased growth rates with eccentric systolic flow.| | PubMed
- Acute type A aortic dissection intimal tears by 64-slice computed tomography: a role for endovascular stent-grafting?| | PubMed
- Hemodynamic determinants of aortic dissection propagation by 2D computational modeling: implications for endovascular stent-grafting.| | PubMed
- Regional mechanical properties of human pulmonary root used for the Ross operation.| | PubMed
- Cerebrospinal fluid amyloid-β (Aβ) as an effect biomarker for brain Aβ lowering verified by quantitative preclinical analyses.| | PubMed
- Correlation of calcification on excised aortic valves by micro-computed tomography with severity of aortic stenosis.| | PubMed
- Patient-specific multiscale modeling of blood flow for coronary artery bypass graft surgery.| | PubMed
- The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations.| | PubMed
- First evidence of depressed contractility in the border zone of a human myocardial infarction.| | PubMed
- A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure.| | PubMed
- Biomechanical comparison of human pulmonary and aortic roots.| | PubMed
- Transcatheter heart valves for failing bioprostheses: state-of-the-art review of valve-in-valve implantation.| | PubMed
- Incidental aortic valve calcification on CT scans: significance for bicuspid and tricuspid valve disease.| | PubMed
- Echo rounds: aneurysm of the anterior mitral valve.| | PubMed
- Comparison of mechanical properties of human ascending aorta and aortic sinuses.| | PubMed
- Post-stenotic dilation: evaluation of ascending aortic dilation with 4D flow MR imaging.| | PubMed
- Operative risks and survival in veterans with severe aortic stenosis: surgery versus medical therapy.| | PubMed
- Valve-in-valve hemodynamics of 20-mm transcatheter aortic valves in small bioprostheses.| | PubMed
- Finite element modeling of the pulmonary autograft at systemic pressure before remodeling.| | PubMed
- Closure of aortic paravalvular leak under intravascular ultrasound and intracardiac echocardiography guidance.| | PubMed
- Transcatheter valve-in-valve implantation for failing bioprosthetic valves.| | PubMed
- Live transference of surgical subspecialty skills using telerobotic proctoring to remote general surgeons.| | PubMed
- Comparison of porcine pulmonary and aortic root material properties.| | PubMed
- Transcatheter aortic valves inadequately relieve stenosis in small degenerated bioprostheses.| | PubMed
- Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest.| | PubMed
- Energy loss due to paravalvular leak with transcatheter aortic valve implantation.| | PubMed
- Valve-in-valve implantation using a novel supravalvular transcatheter aortic valve: proof of concept.| | PubMed
- A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm.| | PubMed
- Biomechanical perspective on the porcine pulmonary root prior to Ross remodeling.| | PubMed
- Migration forces of transcatheter aortic valves in patients with noncalcific aortic insufficiency.| | PubMed
- Aortic valve-in-valve implantation: impact of transcatheter- bioprosthesis size mismatch.| | PubMed
- Usability of robotic platforms for remote surgical teleproctoring.| | PubMed
- Computational fluid dynamics simulation of transcatheter aortic valve degeneration.| | PubMed
- Mechanical properties of surgical glues used in aortic root replacement.| | PubMed
- Retrograde cerebral perfusion and delayed hyperbaric oxygen for massive air embolism during cardiac surgery.| | PubMed
- Significant material property differences between the porcine ascending aorta and aortic sinuses.| | PubMed
- Robotic mammary artery harvest and anastomotic device allows minimally invasive mitral valve repair and coronary bypass.| | PubMed
- A simple correction for anomalous coronary arteries in adults.| | PubMed
- Robotic cardiac surgery: give it more time!| | PubMed
- Invited commentary.| | PubMed
- Asymmetric mechanical properties of porcine aortic sinuses.| | PubMed
- Central nervous system pharmacokinetics of the Mdr1 P-glycoprotein substrate CP-615,003: intersite differences and implications for human receptor occupancy projections from cerebrospinal fluid exposures.| | PubMed
- Percutaneous technique for creation of tricuspid regurgitation in an ovine model.| | PubMed
- Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thrombocytopenia.| | PubMed
- Reversal of direct thrombin inhibition after cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia.| | PubMed
- Profound hypoxemia resulting from shunting across an inadvertent atrial septal tear after left ventricular assist device placement.| | PubMed
- Barrett's esophagus with high grade dysplasia: surgical results and long-term outcome--an update.| | PubMed
- Cerebral hemodynamics changes during retrograde brain perfusion in dogs.| | PubMed
- Training women surgeons and their academic advancement.| | PubMed
- Laparoscopic nephrectomy for autotransplantation.| | PubMed
- Prevalence of aspiration and laryngeal penetration in patients with unilateral vocal fold motion impairment.| | PubMed
- Apoptosis detection in brain using low-magnification dark-field microscopy.| | PubMed
- Assessing the impact of cerebral injury after cardiac surgery: will determining the mechanism reduce this injury?| | PubMed
- Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest.| | PubMed
- Nitric oxide mediates neurologic injury after hypothermic circulatory arrest.| | PubMed
- Relationship of the long thoracic nerve to the scapular tip: an aid to prevention of proximal nerve injury.| | PubMed
- Monosialoganglioside GM1 inhibits neurotoxicity after hypothermic circulatory arrest.| | PubMed
- The role of the monosialoganglioside, GM1 as a neuroprotectant in an experimental model of cardiopulmonary bypass and hypothermic circulatory arrest.| | PubMed
- Neuronal nitric oxide synthase inhibition reduces neuronal apoptosis after hypothermic circulatory arrest.| | PubMed
- Aortic valve replacement in the elderly. Risk factors and long-term results.| | PubMed
- Selective endothelial dysfunction in conscious dogs after cardiopulmonary bypass.| | PubMed
- Pathophysiology of cerebral injury and future management.| | PubMed
- Overcoming rejection in pig-to-primate cardiac xenotransplantation.| | PubMed