Biography
Dr. Ratcliffe received his M.D. degree from Case Western Reserve School of Medicine and completed his General Surgery and Cardiothoracic residencies at the Univeristy of Pennsylvania. Dr. Ratcliffe is certified by the American Board of Surgery and American Board of Thoracic Surgery. His special interest is in the application of finite element analysis or the failing left ventricle. Dr. Ratcliffe has been on the faculty since 1993. Currently, he is Director of the Cardiac Biomechanics Laboratory.
Dr. Ratcliffe is an active member of the American Society for Artificial Internal Organs, American Heart Association, Society of Thoracic Surgeons, Western Thoracic Surgical Association, San Francisco Surgical Society, American Association of Thoracic Surgery, and is a Fellow of the American College of Surgeons.
Education
M.D.-Case Western Reserve University, Cleveland, OHM.D.
B.A. - Denison University, Granville, OH
Internship - John Hopkins Hospital, Baltimore, MD
Residency - John Hopkins Hospital, Baltimore, MD
Residency - University of Pennsylvania Hospital, Philadelphia, PA
Research Fellow - University of Pennsylvania Hospital, Philadelphia, PA
Fellowship - University of Pennsylvania Hospital, Philadelphia, PA
Board Certifications
American Board of Surgery, 1989
American Board of Thoracic Surgery, 1993
Clinical Expertise
Minimally invasive cardiac surgery
Off-pump coronary artery bypass surgery
Valve repair and replacement
Surgery for heart failure
Robotic surgery
Thoracic aortic surgery
Grants and Funding
- Quantitative analysis of left ventriculoplasty: CHF | NIH | 2000-04-17 - 2020-04-30 | Role: Principal Investigator
- Surgery for Ischemic Mitral Regurgitation | NIH | 2008-01-15 - 2013-12-31 | Role: Principal Investigator
Research Interests
- Finite element analysis of failing left ventricle
Publications
- Imaging in Pulmonary Vascular Disease-Understanding Right Ventricle-Pulmonary Artery Coupling.| | PubMed
- All Roads Lead to Rome: Diverse Etiologies of Tricuspid Regurgitation Create a Predictable Constellation of Right Ventricular Shape Changes.| | PubMed
- A finite element model of the cardiac ventricles with coupled circulation: Biventricular mesh generation with hexahedral elements, airbags and a functional mockup interface to the circulation.| | PubMed
- A kinematic model-based analysis framework for 3D Cine-DENSE-validation with an axially compressed gel phantom and application in sheep before and after antero-apical myocardial infarction.| | PubMed
- Finite-element based optimization of left ventricular passive stiffness in normal volunteers and patients after myocardial infarction: Utility of an inverse deformation gradient calculation of regional diastolic strain.| | PubMed
- Ischemia-Mediated Dysfunction in Subpapillary Myocardium as a Marker of Functional Mitral Regurgitation.| | PubMed
- Right Ventricular Shape Distortion in Tricuspid Regurgitation.| | PubMed
- Left ventricular geometry during unloading and the end-systolic pressure volume relationship: Measurement with a modified real-time MRI-based method in normal sheep.| | PubMed
- Myocardial injection of a thermoresponsive hydrogel with reactive oxygen species scavenger properties improves border zone contractility.| | PubMed
- A Novel MRI-Based Finite Element Modeling Method for Calculation of Myocardial Ischemia Effect in Patients With Functional Mitral Regurgitation.| | PubMed
- Transcatheter MitraClip repair alters mitral annular geometry - device induced annular remodeling on three-dimensional echocardiography predicts therapeutic response.| | PubMed
- Mechanical effects of MitraClip on leaflet stress and myocardial strain in functional mitral regurgitation - A finite element modeling study.| | PubMed
- Impact of Mitral Regurgitation Severity and Cause on Effort Tolerance-Integrated Stress Myocardial Perfusion Imaging and Echocardiographic Assessment of Patients With Known or Suspected Coronary Artery Disease Undergoing Exercise Treadmill Testing.| | PubMed
- Left ventricular geometry predicts optimal response to percutaneous mitral repair via MitraClip: Integrated assessment by two- and three-dimensional echocardiography.| | PubMed
- Tissue-based markers of right ventricular dysfunction in ischemic mitral regurgitation assessed via stress cardiac magnetic resonance and three-dimensional echocardiography.| | PubMed
- Short term doxycycline treatment induces sustained improvement in myocardial infarction border zone contractility.| | PubMed
- Correction to: Abstracts : 29th European Congress of Pathology.| | PubMed
- Ischemic Mitral Regurgitation: Abnormal Strain Overestimates Nonviable Myocardium.| | PubMed
- Multiplanar strain quantification for assessment of right ventricular dysfunction and non-ischemic fibrosis among patients with ischemic mitral regurgitation.| | PubMed
- Echocardiography-quantified myocardial strain-a marker of global and regional infarct size that stratifies likelihood of left ventricular thrombus.| | PubMed
- Association of Uneven MitraClip Application and Leaflet Stress in a Finite Element Model.| | PubMed
- Right Ventricular Dysfunction Impairs Effort Tolerance Independent of Left Ventricular Function Among Patients Undergoing Exercise Stress Myocardial Perfusion Imaging.| | PubMed
- Undersized Mitral Annuloplasty Increases Strain in the Proximal Lateral Left Ventricular Wall.| | PubMed
- Neochord placement versus triangular resection in mitral valve repair: A finite element model.| | PubMed
- Suture Forces for Closure of Transapical Transcatheter Aortic Valve Replacement: A Mathematical Model.| | PubMed
- Moderate Ischemic Mitral Regurgitation After Posterolateral Myocardial Infarction in Sheep Alters Left Ventricular Shear but Not Normal Strain in the Infarct and Infarct Borderzone.| | PubMed
- Finite Element Modeling of Mitral Valve Repair.| | PubMed
- Myocardial perfusion pattern for stratification of ischemic mitral regurgitation response to percutaneous coronary intervention.| | PubMed
- Residual Stress Impairs Pump Function After Surgical Ventricular Remodeling: A Finite Element Analysis.| | PubMed
- Progressive design concepts in off-pump left ventricular remodeling mitral valve repair devices.| | PubMed
- Studies on postinfarct left ventricular remodeling: state of the art.| | PubMed
- Effect of mitral annuloplasty device shape and size on leaflet and myofiber stress following repair of posterior leaflet prolapse: a patient-specific finite element simulation.| | PubMed
- A N-terminal truncated intracellular isoform of matrix metalloproteinase-2 impairs contractility of mouse myocardium.| | PubMed
- Myofilament dysfunction contributes to impaired myocardial contraction in the infarct border zone.| | PubMed
- Posterior papillary muscle anchoring affects remote myofiber stress and pump function: finite element analysis.| | PubMed
- Patient-specific finite element modeling of the Cardiokinetix Parachute(®) device: effects on left ventricular wall stress and function.| | PubMed
- Invited commentary.| | PubMed
- Applications of computational modeling in cardiac surgery.| | PubMed
- Measurement of mitral leaflet and annular geometry and stress after repair of posterior leaflet prolapse: virtual repair using a patient-specific finite element simulation.| | PubMed
- Invited commentary.| | PubMed
- Analysis of patient-specific surgical ventricular restoration: importance of an ellipsoidal left ventricular geometry for diastolic and systolic function.| | PubMed
- Biventricular finite element modeling of the Acorn CorCap Cardiac Support Device on a failing heart.| | PubMed
- Left ventricular myocardial contractility is depressed in the borderzone after posterolateral myocardial infarction.| | PubMed
- Left ventricular pressure gating in ovine cardiac studies: a software-based method.| | PubMed
- Invited commentary.| | PubMed
- Finite element modeling of mitral leaflet tissue using a layered shell approximation.| | PubMed
- Material properties of CorCap passive cardiac support device.| | PubMed
- Patient-specific finite element-based analysis of ventricular myofiber stress after Coapsys: importance of residual stress.| | PubMed
- The benefit of enhanced contractility in the infarct borderzone: a virtual experiment.| | PubMed
- Growth and remodeling of the left ventricle: A case study of myocardial infarction and surgical ventricular restoration.| | PubMed
- A coupled biventricular finite element and lumped-parameter circulatory system model of heart failure.| | PubMed
- The effect of mitral annuloplasty shape in ischemic mitral regurgitation: a finite element simulation.| | PubMed
- Electromechanical feedback with reduced cellular connectivity alters electrical activity in an infarct injured left ventricle: a finite element model study.| | PubMed
- Invited commentary.| | PubMed
- Moderate mitral regurgitation accelerates left ventricular remodeling after posterolateral myocardial infarction.| | PubMed
- A novel method for quantifying in-vivo regional left ventricular myocardial contractility in the border zone of a myocardial infarction.| | PubMed
- A novel method for quantifying the in-vivo mechanical effect of material injected into a myocardial infarction.| | PubMed
- Operative risks and survival in veterans with severe aortic stenosis: surgery versus medical therapy.| | PubMed
- Invited commentary.| | PubMed
- Regional left ventricular myocardial contractility and stress in a finite element model of posterobasal myocardial infarction.| | PubMed
- Comparison of the Young-Laplace law and finite element based calculation of ventricular wall stress: implications for postinfarct and surgical ventricular remodeling.| | PubMed
- First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation.| | PubMed
- Dor procedure for dyskinetic anteroapical myocardial infarction fails to improve contractility in the border zone.| | PubMed
- Fluid-Structure Interactions of the Mitral Valve and Left Heart: Comprehensive Strategies, Past, Present and Future.| | PubMed
- Severe aortic stenosis in a veteran population: treatment considerations and survival.| | PubMed
- Effect of adjustable passive constraint on the failing left ventricle: a finite-element model study.| | PubMed
- A method for automatically optimizing medical devices for treating heart failure: designing polymeric injection patterns.| | PubMed
- A computationally efficient formal optimization of regional myocardial contractility in a sheep with left ventricular aneurysm.| | PubMed
- Adaptive generation of multimaterial grids from imaging data for biomedical Lagrangian fluid-structure simulations.| | PubMed
- The use of computational flow modeling (CFD) to determine the effect of left ventricular shape on blood flow in the left ventricle.| | PubMed
- The biomechanics of arterial elastin.| | PubMed
- A simple correction for anomalous coronary arteries in adults.| | PubMed
- National Institutes of Health funding for cardiothoracic surgical research.| | PubMed
- Asymmetric mechanical properties of porcine aortic sinuses.| | PubMed
- Magnetic resonance imaging-based finite element stress analysis after linear repair of left ventricular aneurysm.| | PubMed
- National institutes of health funding for surgical research.| | PubMed
- Cost-utility analysis of treatment with olanzapine compared with other antipsychotic treatments in patients with schizophrenia in the pan-European SOHO study.| | PubMed
- Endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm increases systolic circumferential shortening in sheep.| | PubMed
- The effect of preoperative diastolic dysfunction on outcome after surgical ventricular remodeling.| | PubMed
- Invited commentary.| | PubMed
- Transmural heterogeneity of diffusion anisotropy in the sheep myocardium characterized by MR diffusion tensor imaging.| | PubMed
- Remission and relapse in the outpatient care of schizophrenia: three-year results from the Schizophrenia Outpatient Health Outcomes study.| | PubMed
- Theoretical impact of the injection of material into the myocardium: a finite element model simulation.| | PubMed
- The treatment of ischemic heart failure with surgical ventricular restoration (SVR): new evidence of benefit.| | PubMed
- The effect of anteroapical aneurysm plication on end-systolic three-dimensional strain in the sheep: a magnetic resonance imaging tagging study.| | PubMed
- Left ventricular volume and function after endoventricular patch plasty for dyskinetic anteroapical left ventricular aneurysm in sheep.| | PubMed
- MRI-based finite-element analysis of left ventricular aneurysm.| | PubMed
- Helical myofiber orientation after myocardial infarction and left ventricular surgical restoration in sheep.| | PubMed
- Use of bivalirudin, a direct thrombin inhibitor, and its reversal with modified ultrafiltration during heart transplantation in a patient with heparin-induced thrombocytopenia.| | PubMed
- Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study.| | PubMed
- Akinetic myocardial infarcts must contain contracting myocytes: finite-element model study.| | PubMed
- Myosplint decreases wall stress without depressing function in the failing heart: a finite element model study.| | PubMed
- Effect of preoperative delay on prognosis for patients with early stage non-small cell lung cancer.| | PubMed
- A finite element model of left ventricular cellular transplantation in dilated cardiomyopathy.| | PubMed
- Ventricular remodeling surgery for heart failure: small animals and how to measure an improvement in ventricular function.| | PubMed
- Left ventricular volume reduction by radiofrequency heating of chronic myocardial infarction in patients with congestive heart failure.| | PubMed
- Residual stress produced by ventricular volume reduction surgery has little effect on ventricular function and mechanics: a finite element model study.| | PubMed
- Cardiopulmonary Complications Following Cardiac Surgery.| | PubMed
- Mechanism underlying mechanical dysfunction in the border zone of left ventricular aneurysm: a finite element model study.| | PubMed
- Batista's operation: what have we learned?| | PubMed
- Effect of induction and reperfusion with warm substrate-enriched cardioplegia on ventricular function.| | PubMed
- Collection of process data after cardiac surgery: initial implementation with a Java-based intranet applet.| | PubMed
- Radio frequency heating of chronic ovine infarct leads to sustained infarct area and ventricular volume reduction.| | PubMed
- The effect of diastolic stiffness on ventricular function after partial ventriculectomy: a finite element simulation.| | PubMed
- Ventricular volume, chamber stiffness, and function after anteroapical aneurysm plication in the sheep.| | PubMed
- L-arginine infusion dilates coronary vasculature in patients undergoing coronary bypass surgery.| | PubMed
- The effect of ventricular volume reduction surgery in the dilated, poorly contractile left ventricle: a simple finite element analysis.| | PubMed
- Dynamic three-dimensional imaging of the mitral valve and left ventricle by rapid sonomicrometry array localization.| | PubMed
- Use of sonomicrometry and multidimensional scaling to determine the three-dimensional coordinates of multiple cardiac locations: feasibility and initial implementation.| | PubMed
- Pathogenesis of acute ischemic mitral regurgitation in three dimensions.| | PubMed
- A novel sialyl LewisX analog attenuates neutrophil accumulation and myocardial necrosis after ischemia and reperfusion.| | PubMed
- Changes in passive mechanical stiffness of myocardial tissue with aneurysm formation.| | PubMed
- Left ventricular assist without thoracotomy: clinical experience with the Dennis method.| | PubMed
- Large animal model of ischemic mitral regurgitation.| | PubMed
- Repair of left ventricular aneurysm. Changes in ventricular mechanics, hemodynamics, and oxygen consumption.| | PubMed
- Left ventricular mechanics of ejecting, postischemic hearts during left ventricular circulatory assistance.| | PubMed
- Myocardial oxygen utilization after reversible global ischemia.| | PubMed
- Large animal model of left ventricular aneurysm.| | PubMed
- Measurement of end-systolic pressure-volume relations by intra-aortic balloon occlusion.| | PubMed
- Surgery for left ventricular aneurysm. Early survival with and without endocardial resection.| | PubMed
- Flow dynamics of peripheral venous catheters during extracorporeal membrane oxygenation with a centrifugal pump.| | PubMed
- Changes in left ventricular systolic wall stress during biventricular circulatory assistance.| | PubMed